Comparison of the effect of combined herbal medicine with routine medicine on sperm quality and chromatine integrity in oligoasthenoteratozoospermia me
Phase 3
Recruiting
- Conditions
- Oligoasthenotratosospermia.Male infertility
- Registration Number
- IRCT20200929048878N1
- Lead Sponsor
- Iranian academic center for education culture and research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
Patients with oligo asthenotratospermia(Total sperm count is 15 or less than 15 million per milliliter.The percentage of normal morphology or appearance is less than 4.Sperm motility is less than 40%.
The patient's spouse is fertile.
Have a history of infertility for at least one year.
Exclusion Criteria
History of receiving chemotherapy drugs, corticosteroids, anticoagulants, testosterone, anti-androgens two months before the start of the study
Genital infections, anatomical abnormalities, chromosomal abnormalities, history of genital surgery (varicocele, ...)
Alcohol or drug use
Patients with Ejaculation disorder
Systemic diseases (malignancy, thyroid disease, liver and gallbladder)
Cr>1.5
Sgot>80
Sgpt>80
Hb<10
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sperm count. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: optical microscope.;Sperm motility. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: optical microscope.;Sperm morphology. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: staining.;Sperm DNA fragmentation. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: optical microscope.;Protamine deficiency. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: Fluorescent microscope.
- Secondary Outcome Measures
Name Time Method Follicle-stimulating hormone,Luteinizing Hormone,Testosterone. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: kit.;Malondialdehyde. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: ELISA Kit.;Total antioxidant capacity. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: ELISA Kit.;Erectile quality. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: International Index of Erectile Function Questionnaire (IIEF).;Quality of sexual life. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: Sexual Quality of Life Questionnaire (SQOL).