Effect of Intranasal Vasopressin on Cooperative Behavior in Schizophrenia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Performance in Dictator game
Study Overview
Brief Summary
The study investigates the effect of 40IU of intranasal vasopressin on cooperative behavior in patients with schizophrenia
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Other
- Masking
- Double (Participant, Investigator)
Masking Description
Double
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 18-45 years
- •Diagnosed as Schizophrenia or Schizophreniform disorder as per DSM IV TR
- •At least 7 years of formal education
- •MOCA score >24
Exclusion Criteria
- •Diagnoses of SIADH, Diabetes Insipidus
- •Substance dependence in the past 12 months, excluding nicotine dependence
- •Current comorbid axis 1 psychiatric disorder
- •Hypersensitivity or previous allergy to Vasopressin
- •Serious medical or neurological illness which may interfere with assessment and administration of vasopressin
- •Hypertension
- •Impaired renal functions based on serum creatinine above 1.5
- •Electrolyte imbalance
- •Receiving ECT or has received ECT in the past 8 weeks
- •Clinical history of mental retardation
- •Pregnancy • Lactation
- •Risk of harm to self or others
- •Any significant nasal pathology which may hinder the intranasal absorption of the drug
- •Hearing or visual impairment that significantly affects the comprehension and execution of the study
Arms & Interventions
vasopressin
All subjects will receive bot 40IU of vasopressin and saline placebo in counterbalanced design
Intervention: Vasopressins (Drug)
Placebo
All subjects will receive bot 40IU of vasopressin and saline placebo in counterbalanced design
Intervention: Placebo (Drug)
Outcomes
Primary Outcomes
Performance in Dictator game
Time Frame: 60 minutes
Amount of money shared in dictator game
Performance in stag hunt game
Time Frame: 60 minutes
Security level in stag hunt game
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Naren P Rao
Additional Professor
National Institute of Mental Health and Neuro Sciences, India
