Improvement of Facial Nerve Monitoring in Parotid Surgery by Sugammadex

Completed

• Conditions: Injury to Nerve During Surgery
• Interventions: Drug: sugammadex (Bridion)

• Registration Number: NCT02314234
• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Brief Summary

To investigate the effectiveness of rapid reversal of rocuronium-induced neuromuscular block by sugammadex during IONM of facial nerve during parotid surgery

Detailed Description

Intraoperative neuromonitoring (IONM) of facial nerve has been applied in identifying and preserving facial nerve during parotid surgery. In this setting, even a single dose of nondepolarizing muscle relaxant may lead to delayed and weakened electromyography (EMG) signal in facial nerve monitoring during parotid surgery. The aim of this study was to investigate the effectiveness of rapid reversal of rocuronium-induced neuromuscular block by sugammadex during IONM of facial nerve during parotid surgery

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2014-12-04
• Study First Submitted QC: 2014-12-08
• Study First Posted: 2014-12-11
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-23
• Last Update Posted: 2016-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• undergoing parotid surgery

Exclusion Criteria

• facial nerve injury, renal failure, liver cirrhosis, neuromuscular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sugammadex group	sugammadex (Bridion)	received single dose of rocuronium for anesthesia and sugammadex at skin incision

Primary Outcome Measures

Name	Time	Method
evoked EMG amplitude of facial nerve	up to first post-op day

Trial Locations

Locations (1)

I-Cheng Lu; 🇨🇳 Kaohsiung, Taiwan