Autoimmune-Lymphproliferative Primary Immunodeficiencies: A clinical, immunological and genetic cohort study (AL-PID study, formerly: ALPS study)
Recruiting
- Conditions
- Autoimmune Lymphoproliferative Syndrome other genetically defined or up to now not yet defined primary immunodeficiencies
- Registration Number
- DRKS00011383
- Lead Sponsor
- niversitätsklinikum FreiburgCentrum für Chronische Immundefizienz (CCI)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 600
Inclusion Criteria
1.Chronic benign lymphoproliferation (i.e. splenomegaly +/- lymphadenopathy at 2 sites without infectious or malignant cause)
AND
2.Autoimmune disease (i.e. AI cytopenia OR inflammatory bowel disease OR CNS inflammatory disease OR interstitial lung disease)
OR
one of the two above manifestions
AND
3.At least one factor indicating a primary immunodeficiency (i.e. infection susceptibility OR additional autoimmune or inflammatory manifestations OR hypogammaglobulinemia OR aberrant immunophenotype OR positive family history OR consanguinity)
Exclusion Criteria
No written informed consent of patient or parents (in case of minors) has been obtained
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method se the clinical, immunological and genetic data in this cohort to establish a diagnostic algorithm for patients with AL-PID
- Secondary Outcome Measures
Name Time Method not applicable