Autoimmune inflammation as cause of RelapsIng Symptoms in patients with viral Encephalitis

Recruiting

• Conditions: autoimmune encephalitis; Inflammation of the brain; Viral encephalitis; 10003816; 10047438; 10007951

• Registration Number: NL-OMON55224
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

All patients, aged >16 yearsor older. with viral encephalitis proven by PCR or
serology

Exclusion Criteria

- Patients with encephalitis but no viral pathogen
- Neurosurgical operation or neurotrauma, in the 3 months previous to the
encephalitis episode
- Presence of neurosurgical devices in the central nervous system
- Insufficient mastery of the Dutch language
- Severe cognitive impairment prior to the encephalitis episode

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Identify causes of secondary deterioration or failure to improve after viral<br /><br>encephalitis by studying activation of the immune system and production of<br /><br>autoantibodies.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Proportion of patients with viral encephalitis that fail to improve or have<br /><br>secondary deterioration<br /><br>- Determine if the delayed inflammatory response of the brain can be predicted<br /><br>by clinical characteristics upon presentation, blood or cerebrospinal fluid<br /><br>tests and cranial imaging.</p><br>