NL-OMON52406
Recruiting
Not Applicable
Morphine or Fentanyl for Refractory dyspnea in COPD - MoreFoRCOPD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- chronic bronchitis and emphysema.
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \>\=40 years
- •Read, understood and signed the Informed Consent form
- •COPD GOLD class III or IV, according to GOLD criteria.
- •\- Post\-bronchodilatation FEV1/FVC \< 70% and FEV1 \< 50% pred.
- •Complaints of refractory dyspnea as established by patient and doctor.
- •mMRC score \>\= 3\.
- •Life expectancy of \>\= 2 months.
- •Optimized standard therapy according to Dutch LAN guideline for diagnosis and
- •treatment of COPD.
Exclusion Criteria
- •Other severe disease with chronic pain or chronic dyspnea (a non\-susbstantial
- •component of left sided heart failure is acceptable).
- •Current use of opioids for whatever indication
- •Allergy / intolerance for opioids
- •Psychiatric disease, not related to severe COPD.
- •Exacerbation of COPD eight weeks prior to inclusion or between screening and
- •randomization.
- •Problematic (leading to medical help or social problems) substance abuse
- •during the last five years.
- •Active malignancy, with the exception of planocellular or basal cell
Outcomes
Primary Outcomes
Not specified
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