Transversus Abdominis Plane Block From Intraabdominal Approach in Patients Undergoing Total Abdominal Hysterectomy: a Randomized Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- United Christian Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- postoperative 24hr morphine consumption
Study Overview
Brief Summary
Randomized double blind placebo controlled trial on transversus abdominus plane block approached from abdominal cavity, in patients undergoing total abdominal hysterectomy.
Detailed Description
Potential advantages compared to percutaneous approach are decrease in risk of visceral injury as it is under direct visual and tactile guidance, ease of approach in obese patients, short theatre time for administration, easy to administer.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •ASA physical status I-III
- •Age 18 or above
- •Scheduled to undergo TAH+/- salpingoophorectomy.
- •Scheduled to receive general anaesthesia under standardized anaesthetic regime.
- •Comprehends how to use intravenous patient controlled analgesia (IV PCA).
- •Is willing to complete the postoperative assessment.
- •Understands the nature and purpose of this study and the study procedures and has signed the informed consent form for this study to indicate this understanding.
Exclusion Criteria
- •Known allergy to drugs involved in this study
- •Previously taking medications thought to result in opioid tolerance, or analgesics thought to interfere with subsequent opioid requirement.
- •Undergoing any procedures in addition to TAH+/- salpingoophorectomy.
- •With co-existing pathology resulting in persistent pain requiring analgesics.
- •Wound incision extending to supra-umbilical level.
Outcomes
Primary Outcomes
postoperative 24hr morphine consumption
Time Frame: 24 hours
The primary objective of this study is to demonstrate the effectiveness of tranversus abdominis plane block using the intraabdominal approach in reducing postoperative 24 hours morphine consumption after total abdominal hysterectomy (TAH) where time 0 is taken as time of arrival at PACU.
Secondary Outcomes
- morphine consumption on arrival to post-anaesthetic care unit(PACU) and 4, 12 and 24 hours after.(24hrs)
- Degree on pain according to numerical pain score on arrival to post-anaesthetic care unit(PACU) and 4, 12 and 24 hours after during rest and movement (cough(24hrs)
- incidence of nausea and vomiting(24hours postoperatively)