Role of Exercise for Wound Healing in the Larynx

Not Applicable

Completed

• Conditions: Acute Phonotrauma
• Interventions: Behavioral: Voice rest; Behavioral: Resonant voice; Behavioral: Spontaneous speech

• Registration Number: NCT01009632
• Lead Sponsor: University of Pittsburgh

Brief Summary

The purpose of this study is to explore quantitatively the hypothesis that "resonant voice," may enhance recovery from acute laryngeal phonotrauma, based on molecular assays from human laryngeal secretions and secondarily, clinical tests.

Detailed Description

The objective is to use the following operationalized question: Does a voicing mode shown to correspond to high-amplitude, low impact vocal cord oscillations, "resonant voice," improve the amount and time-course of recovery from acute phonotrauma, compared to vocal rest or spontaneous speech, as measured with molecular assays (primarily) and with behavioral and clinical tests (secondarily)?

Study Timeline

• Study Start: 2004-02
• Primary Completion: 2005-03
• Study Completion: 2005-03
• Status Verified: 2009-11
• Study First Submitted: 2009-11-05
• Study First Submitted QC: 2009-11-06
• Last Update Submitted: 2009-11-06
• Study First Posted: 2009-11-09
• Last Update Posted: 2009-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• males and females who have had voice training and feel they are able to produce loud voice safely;
• ages 18-49;
• generally healthy;
• normal hearing bilaterally at 20 dB to 8,000 Hz; and
• demonstrated ability to produce "resonant voice" during training as determined by the examiner perceptually.

Read More

Exclusion Criteria

• current chronic voice problems;
• current medications that are determined to possibly influence voice (e.g. diuretics, decongestants);
• heightened gag reflex;
• small nasal passage;
• deviated septum; and
• known or suspected allergy to anesthetics.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Voice rest	Voice rest	-
Resonant voice exercise	Resonant voice	-
Spontaneous speech	Spontaneous speech	-

Primary Outcome Measures

Name	Time	Method
Biomarkers in laryngeal secretions	Up to 24-hour post-baseline

Secondary Outcome Measures

Name	Time	Method
Direct Magnitude Estimations of phonatory effort (DME)	Up to 24-hour post baseline
Visual-perceptual ratings of the larynx	Up to 24-hour post baseline
Phonation Threshold Pressure (PTP)	Up to 24-hour post baseline

Trial Locations

Locations (1)

Univesity of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States