Skip to main content
Clinical Trials/NCT06383091
NCT06383091
Recruiting
N/A

Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy

Johns Hopkins University2 sites in 1 country20 target enrollmentJune 3, 2024

Overview

Phase
N/A
Intervention
Not specified
Conditions
Total Thyroidectomy
Sponsor
Johns Hopkins University
Enrollment
20
Locations
2
Primary Endpoint
Scar Quality as assessed by The Patient and Observer Scar Assessment Scale
Status
Recruiting
Last Updated
10 months ago

Overview

Brief Summary

In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment patient complaints of swallowing or voice changes after total thyroidectomy as compared to voice exercise and scar massage alone.

The main questions it aims to answer are:

Will neck massage, stretches and pain science education reduce patient complaints of swallowing changes after total thyroidectomy?

Will neck massage, stretches and pain science education reduce patient complaints of voice changes after total thyroidectomy?

Will neck massage, stretches and pain science education reduce patient complaints of scar tethering and quality changes after total thyroidectomy?

Will neck massage, stretches and pain science education improve quality of life after total thyroidectomy?

Participants will:

Participate in 4 visits with the participant's endocrine/laryngology surgeon. One prior and 3 after surgery for endoscopic evaluation and tests.

Participate in 5 Speech-Language Pathology Sessions for intervention exercises and tests. One prior and 4 after surgery.

Complete a journal of the participant's Home Exercise Practice

Registry
clinicaltrials.gov
Start Date
June 3, 2024
End Date
December 2027
Last Updated
10 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • The study population consists of individuals with malignant or benign thyroid disease scheduled to undergo total thyroidectomy
  • native speakers of English
  • All patients will be greater than or equal to 18 years of age

Exclusion Criteria

  • Participants will be excluded if they have completed voice therapy prior
  • are current smokers
  • have organic vocal fold pathology or clear mucosal changes to the vocal folds that can affect vibration (e.g., vocal fold scar, polyp, or nodules),
  • pre-existing unilateral or bilateral vocal fold paralysis
  • have had prior surgical neck or chest history including central or lateral neck dissection
  • pre- or post-operative abscess or inflammation
  • have a history of radiation, chronic cervical pain or cervicalgia, abnormal baseline swallowing
  • have underlying and, or plan to change supplemental hormones
  • greater than 10% otherwise unexplained weight loss
  • had a recent aspiration pneumonia

Outcomes

Primary Outcomes

Scar Quality as assessed by The Patient and Observer Scar Assessment Scale

Time Frame: Baseline, 1 year

The Patient and Observer Scar Assessment Scale will be used to measure from 0: normal skin, to 10: worst scar imaginable.

Acoustic measures of speaking voice pitch

Time Frame: Baseline, 1 year

Acoustic measurement of average fundamental speaking pitch in Hertz before and after surgery.

Laryngeal sensation

Time Frame: Baseline, 1 year

Using a visual analogue scale of pain - from 0: no pain, to 10: worst pain. Patients will rate their pain.

Swallowing Quality of Life as assessed by the Eating Assessment Tool - 10

Time Frame: Baseline, 1 year

Patients will rate themselves from a 0 - 4 (0: no problem to 4: Severe Problem) on 10 items within the Eating Assessment Tool - 10

Acoustic measures of voice clarity

Time Frame: Baseline, 1 year

Acoustic measurement of relative Cepstral Peak Prominence (dB) in a speaking voice sample.

Acoustic measures of speaking voice quality subjectively

Time Frame: Baseline, 1 year

Clinicians will rate each patient's voice as having or not having each of the following perceptual qualities: Grade, Roughness, Asthenia, Breathiness, Strain. The scale is as follows: 0 (no perceptual quality) to 3 (severe perceptual quality).

Scar Tethering Distance

Time Frame: Baseline, 1 year

Distance in centimeters will be measured between the hyoid bone and scar with swallowing.

Voice Quality of Life as measures by the Voice Related Quality of Life - 10

Time Frame: Baseline, 1 year

Quality of life measures: On a raw scale from 10 - 50 : 10 being no impact on quality of life, and 50 being the greatest impact on quality of life, participants will rate themselves.

Secondary Outcomes

  • Adverse Effects in the Experimental Group(Baseline, 1 year)

Study Sites (2)

Loading locations...

Similar Trials