Ventilator-associated injury (VAI) in chronic home mechanical ventilation: a paradigm switch in order to improve ventilatory support
Completed
- Conditions
- COPD10006436
- Registration Number
- NL-OMON49038
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. RLD: probable or confirmed diagnosis of interstitial pulmonary fibrosis
(IPF) or other fibrotic lung disease of unknown origin.
2. COPD: GOLD stage III or IV
3. Being listed for lung transplantation
Exclusion Criteria
1. Concomitant neuromuscular or systemic/collagen-vascular disease
2. Prior lung surgery or lung volume reduction treatment
3. Being unable to understand the patient information and consent for the study
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The study is an exploratory pilot study. We will investigate both contractile<br /><br>strength and the structure of single diaphragm and intercostal muscle fibres as<br /><br>well as lung injury; i.e. alveolar structure and damage and inflammation in the<br /><br>alveoli. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The study is an exploratory pilot study. We will investigate both contractile<br /><br>strength and the structure of single diaphragm and intercostal muscle fibres as<br /><br>well as lung injury; i.e. alveolar structure and damage and inflammation in the<br /><br>alveoli. </p><br>