Repetitive Transcranial Magnetic Stimulation in Elderly Depressed: Neuronavegated Study
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- DEPRESSION
- Sponsor
- University of Sao Paulo General Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Reduction of the depressive symptomatology on 50% in relation to the initial scored by HAM-D/17 scale, or complete remission of the episode, defined as HAM-D/17 score ≤ 7 at the end of the treatment.
- Last Updated
- 14 years ago
Overview
Brief Summary
This double-blind, controlled and randomized study intents to investigate the antidepressive response of rTMS on the elderly population.This is the first neuronavegated pulse intensity corrected study of rTMS in elderly depressed patients.
Detailed Description
Most part of the studies uses samples of severe depressive patients with refractoriness and/or psychotic symptoms, which leave lacuna about the effects on depressive disorder with low or moderate scores. The literature is poor about the use of Repetitive Transcranial Magnetic Stimulation (rTMS) in the old age population.Therefore, we chose this group to research for the antidepressive effect of TMS; other interests are to identify modifications in the magnetic resonance imaging, evaluate cognitive functions and to verify the occurrence of collateral effects and safety use for this specific population.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •metallic cerebral implants
- •history of severe trauma or brain injury
- •organic brain disease
- •severe somatic disease
- •history of other psychiatric diseases
- •history of Epilepsy
- •Non cooperating patients
- •Scales and Tests of clinical evaluation:
- •Hamilton Depression Rating Scale-17 items
- •Geriatric Depression Scale (GDS)
Outcomes
Primary Outcomes
Reduction of the depressive symptomatology on 50% in relation to the initial scored by HAM-D/17 scale, or complete remission of the episode, defined as HAM-D/17 score ≤ 7 at the end of the treatment.
Time Frame: 30 months
evaluation also by Geriatric Depression Scale (GDS)
Secondary Outcomes
- Reduction of the depressive symptomatology on 50% in relation to the initial scored by HAM-D/17 scale, or complete remission of the episode, defined as HAM-D/17 score ≤ 7 at the end of the treatment.(30 months)