The Effect of a Targeted Exercise Program on Balance and Postural Responses in Patients With Multiple Sclerosis (MS)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Miami
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Change in reaction time
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to examine the effects of a postural adjustment, targeted training program on balance ability and postural responses anticipatory postural adjustments (APA) and compensatory postural adjustments (CPA) in individuals with MS
Detailed Description
All participants participated in individual training program aimed at improving balance ability and postural adjustments. The training program and individual activities were based on previously published programs and motor learning principles, and consists of 18, 1-hour training sessions over six weeks (3 sessions/week). Training occurred in person 2 days a week (in person training) and at home (home exercise program) 1 day a week, for a total of 3 sessions per week. The duration of training sessions were 60 minutes per session for a total of 1,140 minutes of training. The exercise room temperature was centrally regulated (23.3 degrees C).
Investigators
James Moore
Associate professor of clinical
University of Miami
Eligibility Criteria
Inclusion Criteria
- •Must be18 to 70 years of age.
- •Medical diagnosis of MS confirmed by a neurologist.
- •Ability to stand independently without any aid for at least 3 minutes.
- •A Patients determined disease steps (PDDS) score of 5 or lower.
- •Normal or corrected-to-normal vision.
- •English or Spanish speaking.
Exclusion Criteria
- •MS-related exacerbation or medication change in the past two months.
- •Presence of concurrent neurological or orthopedic disorders.
- •Unable to perform the experimental tasks.
Outcomes
Primary Outcomes
Change in reaction time
Time Frame: Baseline, 6 weeks (post intervention)
Measure in seconds
Change in endpoint excursion percentage
Time Frame: Baseline, 6 weeks (post intervention)
measure of endpoint excursion in a percentage out of a100
Change in balance ability as measured by the BESTest
Time Frame: Baseline, 6 weeks (post intervention)
The Balance Evaluation Systems Test (BESTest) will be used to measure balance ability. Items are scored from 0 (severe impairment) to 3 (no impairment), with a total score of 108. A higher score suggests better balance ability.
Change in movement velocity
Time Frame: Baseline, 6 weeks (post intervention)
Measure in degree per second
Change in CPA as measured by microvolts
Time Frame: Baseline, 6 weeks (post intervention)
Postural muscles CPA in microvolts
Change in muscle responses latency as measured by MCT
Time Frame: Baseline, 6 weeks (post intervention)
The Motor Control test (MCT) measures the subject's ability to generate a motor response latency to a sudden surface translation in a forward and backward direction at three different magnitudes (small, medium, and large). Latency: The time-lapse between the perturbation onset and the subject response for each limb. The latency is reported in milliseconds.
Change in directional control percentage
Time Frame: Baseline, 6 weeks (post intervention)
measure of directional control in a percentage out of a100
Change in maximum excursion percentage
Time Frame: Baseline, 6 weeks (post intervention)
measure of maximum excursion in a percentage out of a100
Change in postural muscles responses latency as measured by Electromyography (EMG)
Time Frame: Baseline, 6 weeks (post intervention)
Postural muscles responses onset latency in seconds
Change in APA as measured by microvolts
Time Frame: Baseline, 6 weeks (post intervention)
Postural muscles APA measured in microvolts
Secondary Outcomes
- Change in balance confidence as measured by ABC(Baseline, 6 weeks (post intervention))
- Change in quality of life as measured by the MSQoL-54(Baseline, 6 weeks (post intervention))