ebulized colistin in pneumonia

Phase 3

Recruiting

• Conditions: Ventilator-associated pneumonia.; Pneumonia due to Klebsiella pneumoniae; J15.0

• Registration Number: IRCT20190616043906N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 March 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Diagnosis of pneumonia 48 hours after intubation (radiographical, laboratory and clinical findings along with a positive tracheal aspirate culture)

Exclusion Criteria

Signs of previous pneumonia at the time of intubation
No concomitant antibiotics indicated to treat pneumonia other than the study (but allowed for other infections)
Patients with a positive culture but no clinical and radiological findings for pneumonia
An antibiogram sensitive to any antibiotocs else than polymixins
Any history of allergy and seizure caused by Carbapenems/Colistin

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical response of pneumonia to the treatment regimen. Timepoint: Days 2 and 7. Method of measurement: Evaluating vital signs, oxygenation, laboratory and hemodynamic parameters.;Incidence of acute kidney injury. Timepoint: Days 2 and 7. Method of measurement: According changes in serum creatinine levels and urine volume.