A clinical trial to study the effect of nebulization of Colistin or Amikacin for prevention of ventilator-associated pneumonia in patients requiring ventilatory support in intensive care unit.
- Conditions
- Health Condition 1: J22- Unspecified acute lower respiratory infection
- Registration Number
- CTRI/2024/06/068660
- Lead Sponsor
- Department of Anaesthesiology and Critical Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients requiring mechanical ventilation for more than 72 hours.
Grossly purulent sputum or pneumonia on admission; new and persistent infiltrates on chest radiography within 48 hours from admission.
Severe chronic obstructive pulmonary disease (COPD) or preexisting lung disease requiring long-term inhalation drug therapy.
Long-term therapy with corticosteroids or immunosuppressive drugs, human immunodeficiency virus infection, cancer.
Colonization or infection with a strain resistant to colistin and amikacin on admission.
Acute kidney injury on the day of inclusion. Patients undergoing renal replacement therapy or for whom a decision had been made to initiate renal replacement therapy can be included whatever the KDIGO stage.
Chronic kidney failure.
Pregnancy and breastfeeding women.
Allergy to colistin or amikacin.
Myasthenia gravis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method