Colistin infusio

Phase 4

Recruiting

• Conditions: Kidney failure.; Acute kidney failure

• Registration Number: IRCT20160713028901N5
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Age 18 to 50 years
Receiving colistin at a dose of 4.5 million units every 12 hours (or an equivalent dose according to the patient's kidney function)
Creatinine clearance above 50 ml/min at the beginning of the study
No history of acute kidney injury (based on history and medical history)
Failure to receive other nephrotoxic drugs such as aminoglycosides, amphotericin B, cyclosporine, tacrolimus, furosemide and NSAIDs
Not receiving other antioxidant supplements such as vitamins C and E

Exclusion Criteria

Recent use of colistin in the last 7 days
Using colistin for less than 3 days
Dialysis before starting treatment

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum creatinine level (SCr). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: Hospital laboratory.;Blood urea nitrogen (BUN). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: Hospital laboratory.;Creatinine clearance (CrCl). Timepoint: before starting the treatment, during the treatment for one day in between and also 12 hours after the last dose of colistin on the tenth day of treatment with this antibiotic (before receiving any other dose of colistin). Method of measurement: calculating by equation.