Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise

Not Applicable

Completed

• Conditions: Oxidative Stress
• Interventions: Device: Electrolyzed alkaline reduced water generator

• Registration Number: NCT05673395
• Lead Sponsor: Kyu Jae Lee

Brief Summary

The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. The main question\[s\] it aims to answer are:

* \[question 1\] Can pH 9.5 EARW reduce oxidative stress compared to purified water (PW)

* \[question 2\] Can pH 9.5 EARW decrease fatigue markers in blood

Participants will drink water from the experimental device after high-intensity exercise. Blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water.

Researchers will compare EARW group and PW group to see the anti-oxidative and anti-fatigue effects.

Detailed Description

This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after highly intense exercise.

The participants were divided into two groups, wherein they consumed either purified water (PW group) or EARW (EARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water.

For the anti-oxidative effect, ROS, NO, GPx, and MDA levels were measured. For the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.

Study Timeline

• Study Start: 2022-06-13
• Primary Completion: 2022-06-30
• Study Completion: 2022-06-30
• Study First Submitted: 2022-12-19
• Study First Submitted QC: 2022-12-31
• Status Verified: 2023-01
• Study First Posted: 2023-01-06
• Last Update Submitted: 2023-01-13
• Last Update Posted: 2023-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• healthy male participants aged 19-25 years
• physically active with a normal body mass index (BMI)
• had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study.

Exclusion Criteria

• any kind of visible or known disease
• hypertension,
• musculoskeletal injuries in the previous three months,
• breathing difficulties,
• metabolic diseases,
• autoimmune disease,
• rash,
• urticaria.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
EARW group	Electrolyzed alkaline reduced water generator	This group drink electrolyzed alkaline reduced water (EARW, pH 9.5) 10 mL/kg body weight in 10 min after exercise.
PW group	Electrolyzed alkaline reduced water generator	PW is purified water generated from sham device, and PW group drink 10 mL/kg body weight in 10 min after exercise.

Primary Outcome Measures

Name	Time	Method
EARW consumption is effective in reducing oxidative stress	15 minutes	Reactive oxygen species, nitric oxide, glutathione peroxidase, malondialdehyde

Secondary Outcome Measures

Name	Time	Method
The effects of EARW consumption on exercise-induced fatigue markers in healthy young adults	15 minutes	Lactate levels, phosphate levels, cytokines

Trial Locations

Locations (1)

Wonju Severance Christian Hospital; 🇰🇷 Wonju, Ganwon-do, Korea, Republic of