EUCTR2011-000911-26-DE进行中（未招募）不适用
Heart rate control after acute myocardial infarct - STEMI
niversity of Cologne0 个研究点开始时间: 2011年4月13日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Acute st-segment elevation myocardial infarction (time between symptom onset and PCI < 6 hours) with successful PCI (TIMI III°)
- •Killip Klassification I, II
- •Written informed consent
- •Resting heart rate = 60 bpm
- •Age above 18 years
- •Mean blood pressure = 65 mmHg
- •Systolic blood pressure > 90mmHg
- •Medication with Heparin (weight adapted), clopidogrel ans aspirin before PCI
- •SO2 > 90%
- •Elevated heart rate (= 60/min)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range: 0
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 50
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 50
排除标准
- •Mean blood pressure < 65 mmHg
- •Incomplete PCI success (TIMI < III)
- •Cardiogenic shock
- •Killip Klassification III, IV
- •Symptomatic AV conduction block II°, III°
- •Catecholamin therapy
- •Heart rate < 60/min.
- •Severe peripheral artery disease (Fontaine > IIb)
- •Moderate to severe renal impairment (Serum-creatinin > 2 mg/100ml)
- •Severe liver dysfunction
- •Severe acidosis (pH < 7,2)
- •Known contraindications for Brevibloc (e.g. asthma bronchiale) or known intolerance to Brevibloc
- •Participation in other interventional studies
- •Person related to the sponsor or investigator
- •Unterbringung in einer Anstalt aufgrund gerichtlicher oder behördlicher Anordnung
- •Subjects who were not eligible for follow-up visits (e.g. due to long distance between study hospital and home adress)
- •Women in whom a pregnancy cannot excluded
- •Missing safe contraception (hormonal or copper spirale)
- •Patients without guidelines recommended therapy previosly to PCI
- •Patients in whom anamnestic the symptom onset was > 6 hours or first laboratory tests indicate (LDH > 280U/I) that the myocardial infarction onset was more than 6 hours and in whom no other reasons for elevated LDH are present.
- •Unsuccessful PCI
- •Symptom onset > 6 hours
研究者
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