The study of ANagliptin effects on Glucagon LEvels of type 2 DM patients using insulin / ANGLE study

Not Applicable

• Conditions: Type 2 diabetes Mellitus (T2DM)

• Registration Number: JPRN-UMIN000024399
• Lead Sponsor: Juntendo University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-10-13
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Patients who fall into any of the following criteria are unable to participate in the study. 1. Patients with type 1 diabetes mellitus 2. Patients with insulin dose increased 4 units during the observation times [-12 weeks from baseline] 3. Patients with kind of insulin preparation changed during the observation times 4. Patients who have an experience of taking anagliptin in the past 5. Patients with BMI 30 kg/m2 or greater 6. Patients with severe liver impairment (e.g. decompensated cirrhosis), or either AST or ALT 100 IU/L or higher during the observation times 7. Patients with severe renal impairment (e.g. renal failure), or serum creatinine 1.5 mg/dL or higher during the observation times 8. Patients with severe heart impairment (e.g. heart failure, unstable angina), or have myocardial infarct or angina attack within 24 weeks of the observation times 9. Stroke (cerebral infarction, brain hemorrhage) within 24 weeks before providing consent 10. Patients with malignancy 11. Patients with severe diabetic complications (neuropathy, retinopathy, and nephropathy) 12. Patients with severe ketosis, diabetic coma or precoma 13. Patients with endocrine disease which needs more than hormone replacement therapy (e.g. pituitary, thyroid, or adrenal disease) 14. Patients who have moderate to severe anemia (hemoglobin is below 9.5g/dL) 15. Patients with intestine disease which shows abnormality in digestion and absorption 16. Patients with a medical history digestive organ ablation (excepting cutting appendix) 17. Patients who are excessive alcohol drinkers (e.g. an average of 3 Go of Japanese wine, or 3 large bottles of beer, or more) 18. Patients with other reasons that the responsive investigators or other investigators think inappropriate to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified