跳至主要内容
临床试验/CTRI/2018/12/016699
CTRI/2018/12/016699尚未招募不适用

Prevalence and factors associated with Sarcopenia in Liver Cirrhosis – A cross-sectional study

Manipal Academy of Higher Education1 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2018年12月20日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
130
试验地点
1
主要终点
Prevalence of Sarcopenia in Liver cirrhosis in this subgroup of patients

研究概览

简要总结

Sarcopeniais defined as poor muscle health, in terms of mass as well as function. It is one of the common complications of liver cirrhosis however frequently goesunrecognized, despite it negatively impacting survival, quality of life, andprognosis post liver transplant. There isevidence to show that skeletal muscle abnormalities are related to poor outcomein cirrhosis as well as after liver transplantation. Several establishedprognostic models of cirrhosis such as Child–Pugh and MELD scores do notinclude objective nutritional assessment. There have been no studies measuringthe prevalence of Sarcopenia in coastal Karnataka, and hence this study aims toascertain the prevalence and also to test for predictors of Sarcopenia, so asto guide future studies involving intervention in the form nutritional build-upbefore undergoing liver transplantation.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 75.00 Year(s)(—)
性别
All

入选标准

  • Patients with biochemical, radiologic or histopathologic evidence (wherever available) of liver cirrhosis.

排除标准

  • Patients with other conditions that can cause muscle wasting like chronic renal failure, malignancy, chronic inflammatory / infectious diseases [HIV, TB, HCC, chronic pancreatitis and with long standing Diabetes Mellitus [ >10 years].

结局指标

主要结局

Prevalence of Sarcopenia in Liver cirrhosis in this subgroup of patients

时间窗: 6 months

Assessment of reliable factors associated with development of Sarcopenia in Liver cirrhosis

时间窗: 6 months

次要结局

  • Correlation of Sarcopenia with consequences and complications of liver cirrhosis and portal hypertension, also with CTP and MELD-Na scores(6 months)

研究者

申办方类型
Private medical college

研究点 (1)

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