Sarcopenia in Liver Cirrhosis – A cross-sectional study

Not yet recruiting

• Conditions: Other and unspecified cirrhosis ofliver,

• Registration Number: CTRI/2018/12/016699
• Lead Sponsor: Manipal Academy of Higher Education

Brief Summary

*Sarcopenia*is defined as poor muscle health, in terms of mass as well as function. It is one of the common complications of liver cirrhosis however frequently goesunrecognized, despite it negatively impacting survival, quality of life, andprognosis post liver transplant. There isevidence to show that skeletal muscle abnormalities are related to poor outcomein cirrhosis as well as after liver transplantation. Several establishedprognostic models of cirrhosis such as Child–Pugh and MELD scores do notinclude objective nutritional assessment. There have been no studies measuringthe prevalence of Sarcopenia in coastal Karnataka, and hence this study aims toascertain the prevalence and also to test for predictors of Sarcopenia, so asto guide future studies involving intervention in the form nutritional build-upbefore undergoing liver transplantation.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2018-12-12
• Study Start: 2018-12-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Patients with biochemical, radiologic or histopathologic evidence (wherever available) of liver cirrhosis.

Exclusion Criteria

Patients with other conditions that can cause muscle wasting like chronic renal failure, malignancy, chronic inflammatory / infectious diseases [HIV, TB, HCC, chronic pancreatitis and with long standing Diabetes Mellitus [ >10 years].

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of Sarcopenia in Liver cirrhosis in this subgroup of patients	6 months
Assessment of reliable factors associated with development of Sarcopenia in Liver cirrhosis	6 months

Secondary Outcome Measures

Name	Time	Method
Correlation of Sarcopenia with consequences and complications of liver cirrhosis and portal hypertension, also with CTP and MELD-Na scores	6 months

Trial Locations

Locations (1)

Kasturba Hospital; 🇮🇳 Udupi, KARNATAKA, India

Kasturba Hospital

🇮🇳Udupi, KARNATAKA, India

Neil Palkhiwala

Principal investigator

9099941005

npalkhiwala7@gmail.com