Impact of Supplemental Parenteral Nutrition (SPN) on Infection Rate, Duration of Mechanical Ventilation and Rehabilitation in Intensive Care Unit Patients: A Quality Control Program for the Implementing of New Nutrition Guidelines
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Critically Ill
- Sponsor
- University Hospital, Geneva
- Enrollment
- 305
- Locations
- 2
- Primary Endpoint
- Documented Infection Rate
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Rationale: Enteral nutrition (EN) in the intensive care (ICU) patients is recommended as a standard of care. However, EN alone is often associated with insufficient energy intakes and increased complication rates. Recently the investigators proposed to decrease this deficit by combining EN and supplemental parenteral nutrition (SPN) whenever EN is insufficient (< 60% of their predicted energy needs) at day 3 after admission in the ICU.
Objective: This study aims at: a/ investigating if the delivery of optimal nutrition support (100 % of predicted energy targets) in ICU patients by the combined administration of SPN and EN optimizes their clinical outcome; b/ implementing the new ICU nutrition guidelines.
Study design: Prospective, controlled, randomized clinical study.
Study site: Service of Intensive Care, Geneva University Hospital.
Patient population: 220 ICU patients to be included: expected length of stay > 5 days, expected survival > 7 days, no contraindication to EN, obtained informed consent from themselves or their next of keen.
Exclusion criteria: refusal of consent, age < 18 years, short bowel syndrome, significant persistent gastrointestinal dysfunction with ileus, high output proximal fistula (> 1,5 liter/d), patients receiving PN.
Nutrition: At day 3 after admission, if energy input is < 60%; patients are randomized into either the "Control group" (EN alone) or the "SPN group" (EN + PN) to reach 100% of their predicted energy needs. Tight glycaemic control (target 6.0 to 8.3 mmol/l) to be achieved according to our local practice by insulin administration.
Study endpoints:
- Primary: nosocomial infections (CDC criteria)
- Secondary: Mechanical ventilation duration, ICU and hospital length of stay, antibiotic free days, ICU complications (extra-renal epuration, neurological, cardiac and respiratory complications), energy and protein balance, 28 days clinical outcome.
Detailed Description
Introduction: Nutritional support of the intensive care (ICU) patients is recommended as a standard of care. It is also strongly recommended to start enteral feeding as soon as possible whenever the gastrointestinal tract is functioning (1). However, studies have repeatedly shown that with enteral support alone, insufficient energy and protein intakes often occur (2). The resulting energy and protein deficit is associated with an increased complication rate in ICU patients (3-5). Recently we proposed to decrease this deficit by promoting a combined nutrition support by enteral nutrition (EN) and supplemental parenteral nutrition (SPN) whenever EN is insufficient (6). Contrary to former beliefs, recent meta-analyses show that parenteral nutrition (PN) does not carry excess mortality (7, 8). These reports convey a concept that is a major break-through in current routine of nutritional support in ICU patients by promoting a much wider use of PN. SPN could be the optimal modality to provide the calculated energy targets if this cannot be reached by EN alone. To improve ICU patient's outcome and minimise complications, we propose to implement feeding protocols which combine both EN and PN, when EN is insufficient to cover more than 60% of caloric needs at day 4 to reach 100% of the energy targets by adding PN from day 4 (6). Hypothesis: The administration of SPN, in ICU patients receiving \< 60% of targeted energy needs by EN alone, has a positive impact on their clinical outcome by optimising their nutritional support (reduced infectious complications rate, mechanical ventilation days, duration of ICU and hospital length of stay and rehabilitation). Objective: The aim of the present study is to investigate if the delivery of optimal nutrition support (100 % of predicted energy targets) in ICU patients achieved with the combined administration of SPN and EN optimizes their clinical outcome.
Investigators
HEIDEGGER CP
Deputy head physician
University Hospital, Geneva
Eligibility Criteria
Inclusion Criteria
- •Expected ICU stay \> 5 days
- •Expected survival \> 7 days
- •No contraindication to EN
- •Obtained informed consent
Exclusion Criteria
- •Refusal of consent
- •Age \< 18 years
- •Short bowel syndrome
- •Significant persistent gastrointestinal dysfunction with ileus
- •High output proximal fistula (\> 1.5 liter/d)
- •Patients receiving PN
Outcomes
Primary Outcomes
Documented Infection Rate
Time Frame: 20 days
Infection, defined according to CDC criteria during the ICU and hospital stay, occurrence between day 9 and day 28
Secondary Outcomes
- Total Energy Intake During the Intervention Period , Between Day 4 and Day 8.(5 days)
- Antibiotic Free Days(20 days)
- General Mortality(28 days)
- Days in ICU(28 days)
- Protein Delivery During the Intervention Period From Day 4 to Day 8(5 days)
- Hours on Mechanical Ventilation in All Patients(28 days)
- ICU Mortality(28 days)
- Days in Hospital(28 days)