Pilot Study on Koebner Induction in Patients With Plaque Psoriasis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 15
- 主要终点
- Positive Koebner Phenomena (K+)
研究概览
简要总结
Patients (n=15) with skin psoriasis, minimum age 18 years, without systemic immunomodulatory treatment will be subject to Koebner induction on arms and legs given that they have given written consent and that they have self-reported Koebner.
详细描述
PSODEEP2 PILOT STUDY
Study subject recruitation:
Individuals fulfilling inclusion and exclusion criteria will be identified and contacted from the PSODEEP1 study (ethical application2023-00571-02 and 2022-02835-01), advert in social media, advert in newsletter/magazine sent out by patients organizations (Ung med Psoriasis or Psoriasisförbundet) or through direct contact with patients visits in dermatology department (n = 15).
Inclusion criteria:
Psoriasis skin disease. Self-reported experience of Koebner phenomena. Age 18 years or older. Ability to comprehend study information. Signed and dated informed consent.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Self reported Koebner
- •Diagnosis of skin psoriasis
排除标准
- •Systemic immunomodulatory treatment (including narrowband UVB)
研究组 & 干预措施
Koebner induction
Koebner will be induced on area 22mm in diameter on upper bilateral arms and anterior bilateral thighs.
干预措施: Tape-stripping (Other)
结局指标
主要结局
Positive Koebner Phenomena (K+)
时间窗: 7-21 days after induction
Psoriasis lesion develops at site of provocation/induction
Negative Koebner Phenomena (K-)
时间窗: 21 days after induction
No psoriasis lesion develops at site of provocation/induction
次要结局
- Stratum corneum proteomics(At baseline and at time of K+ assessment or day 21 if K-)
研究者
Albert Duvetorp
Principal Investigator
Skane University Hospital