Low-dose Computer Tomography in Follow-up of Soft Tissue Sarcomas
- Conditions
- Sarcoma,Soft Tissue
- Interventions
- Diagnostic Test: ultra-low-dose computed tomography
- Registration Number
- NCT05813808
- Lead Sponsor
- Helsinki University Central Hospital
- Brief Summary
The goal of this interventional study is to compare sensitivity of regular chest x-ray to ultra-low-dose computed tomography to find pulmonary relapse in follow-up of soft tissue sarcoma. The main question\[s\] it aims to answer are:
* Is ultra-low-dose computed tomography more sensitive than regular chest x-ray to find pulmonary relapse?
* Does ultra-low-dose computed tomography detect the most fast-growing pulmonary metastases earlier than regular chest x-ray?
Participants will have seven ultra-low-dose computed tomography imagings in addition to simultaneous routine protocol of chest x-rays. Participants therefore work as their own controls.
- Detailed Description
After primary treatment with curative intent for soft tissue sarcoma, patients fulfilling the inclusion criteria and giving informed consent are enrolled. In study protocol patients have their regular chest x-ray once in two months plus ultra-low-dose computed tomography imaging is repeated seven times during the first two years of follow-up. After two years patients without detectable metastases continue in regular follow-up program. The aims of this prospective comparative study are to investigate whether ultra-low-dose computed tomography is more accurate than chest x-ray in soft tissue sarcoma and especially whether the most fast-growing pulmonary metastases could be detected earlier.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- primary high grade soft tissue sarcoma with no metastases at diagnoses or during treatment and treatment with curative intent.
- metastases at diagnoses or during treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description chest x-ray and ultra-low-dose computed tomography ultra-low-dose computed tomography -
- Primary Outcome Measures
Name Time Method Number of patients with pulmonary relapse detected by ultra-low-dose CT performed according to a pre-defined schedule 2 years Number of patients with pulmonary relapse detected by chest x-ray performed according to a pre-defined schedule 2 years Number of patients with pulmonary relapse by symptoms 2 years Pulmonary relapse based on patient-reported symptoms leading to positive finding in x-ray and or conventional chest CT between two control imaging rounds.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Helsinki University Hospital Comprehensive Cancer Center
🇫🇮Helsinki, Valitse Alue, Osavaltio Tai Maakunta, Finland