Luteal-Phase GnRH Agonist Administration in Frozen-Thawed IVF Embryo Transfer Cycles
- Registration Number
- NCT00542126
- Lead Sponsor
- Shaare Zedek Medical Center
- Brief Summary
Supraphysiological hormonal stimulation enables collecting many oocytes in an In-Vitro Fertilization treatment, but may have a negative effect on uterine function and contribute the fact that the majority of preembryos placed in the uterus fail to implant.
Several medical agents were shown to be beneficial when given in the luteal phase of an IVF cycle, but the optimal regimen has not been yet determined. In 2006, a European group reported that addition of GnRH analog (Decapeptyl) as luteal support in IVF cycle significantly improved pregnancy and delivery rates. It is not known whether this positive effect influences the corpus luteum, embryo or the uterus. The researchers sought to evaluate the effect of GnRH administration as luteal support in frozen-thaws IVF cycle.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- Not specified
IVF patients transfer of a minimum of two medium-quality thawed embryos in IVF
- Two or more fresh IVF embryo transfer or three or more thawed embryos transfer with no pregnancy.
- maximal endometrial thickness < 6 mm or intracavitary fluid at the time of embryo transfer on previous cycles
- Untreated hydrosalpinges
- intracavitary mass
- submucous myoma
- known allergy to one of medical agents used in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Decapeptyl 0.1 mg after embryo transfer GnRH analog administration following embryo transfer
- Primary Outcome Measures
Name Time Method pregnancy and delivery rates
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
IVF unit, Shaare-Zedek Medical Center
🇮🇱Jerusalem, Israel