The Effects of Exercise Training on Physical Activity Level, Daily Living Activities and Participation in Children With Hemophilia

Istanbul University - Cerrahpasa (IUC)2 个研究点分布在 1 个国家目标入组 30 人开始时间: 2020年2月20日最近更新: 2022年7月11日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 30
试验地点: 2
主要终点: Hemophilia Joint Health Scoring (HJHS)

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study aims to investigate the effects of an individually planned exercise program, counseling and family education on the followings in patients with hemophilia (PWH);

To examine the joint range of motion, muscle strength and functional status.
To evaluate the level of physical activity and daily living activities
To aim to determine the amount of change after participation.

详细描述

Hemophilia is defined as bleeding in the musculoskeletal system and soft tissues as a result of the lack of clotting factors in the blood. Recurrent attacks of hemarthrosis cause pain, also because of the pain patients tend to use joints less than usual. The decrease in joint movement makes it harder to return to active movement again. There is a limited literature on the effects of exercise on children with hemophilia.

Hemophilia is a hereditary bleeding disorder that develops as a result of factor VIII or IX deficiency; it is a rarely seen disease that discloses itself by hemarthrosis and intramuscular bleeding. Factor VIII deficiency is called Hemophilia A and Factor IX deficiency is called Hemophilia B. This disease is inherited by the X chromosome and passes on to male children through female carriers. Although Hemophilia A is observed rarely, one in about 5,000-10,000 male births, its frequency is still 5-6 times higher than Hemophilia B. Around 70% of hemophilia A patients have more severe disease, however, this rate is approximately 50% in hemophilia B.

Hemophilia patients experience bleeding in the musculoskeletal system and soft tissues as a result of the lack of clotting factors in the blood. Recurrent attacks of hemarthrosis cause pain, also because of the pain patients tend to use joints less than usual. Decrease in joint movement makes it harder to return to active movement again in the majority of the cases, bleeding occurs into the joint (mostly the knee, elbow and ankle) and only a small part of the bleedings occurs into the muscle (especially the iliopsoas, calf and forearm muscles).

In order to be able to participate according to the international classification of functions of health (ICF), it is prioritized that the activities are functional.

Targeted treatment is a functional treatment application that conforms to ICF's "activities and participation among children. An activity is carrying out of a task or movement by an individual and the difficulties faced while carrying out the tasks or movements is called limitations. Participation means the individual's being in life. In life conditions, problems confronted are participation restrictions. Activity limitations can often lead to participation restrictions.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Factorial
主要目的: Prevention
盲法: None

入排标准

年龄范围: 8 Years 至 18 Years（Child, Adult）
性别: Male
接受健康志愿者: 否

入选标准

•Being in the 7-18 age range
•Being diagnosed with hemophilia A or B
•Having an ongoing prophylactic treatment
•Having a heavy or middle Factor level
•Volunteering to exercise at 2 days a week in the intervention group within the scope of the research
•Being able to communicate in Turkish written and verbal

排除标准

•Being in period of active bleeding
•Having Body mass index over 30 kg / m²
•Having an additional neurological diagnosis that will influence work and cooperation