A study of the effects of Simvastatin on neutrophil function in elderly subjects - Improving Neutrophil responses in the healthy elderly

niversity of Birmingham0 个研究点目标入组 24 人开始时间: 2012年1月6日最近更新: 2019年11月25日

适应症

试验速览

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•Inclusion Criteria 1. Age > 60 years 2. Competent to provide informed consent and participate 3. MRC Dyspnoea scale < 2 4. Normal lung function (FEV1 > 80% predicted, FVC > 80% predicted) 5. Normal peripheral oxygenation (as assessed by pulse oximetry, with oxygen saturations above 92%) 6. Free from medications known to alter immune cell function (as outlined in protocol) 7. No clinical evidence of acute infection or chronic illness. 8. Normal liver and kidney function as assessed by peripheral blood liver function tests, urea and creatinine and urinary dipstick.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range 0
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 33

•Exclusion criteria 1. Unable to provide informed written consent 2. History of significant chronic illness including Diabetes, COPD, Asthma, TB, Bronchiectasis, Malignancy, Auto immune disease, Cardiovascular disease. 3. Clinical evidence of acute viral or bacterial infection 4. Any regular medical therapies that may alter immune function 5. Declines to provide permission for GP to be informed 6. Any contraindications for statin therapy (hypersensitivity or abnormal renal or liver function tests)

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