Comparison of the effect of Dexmedetoidine (a drug which causes sedation lowers blood pressure and heart rate) on haemodynamic response (changes in blood pressure and heart rate) during Laparoscopic cholecystectomy (during laparoscopic cholecystectomy heart rate & blood pressure is increased)

Not Applicable

Completed

• Conditions: Health Condition 1: null- American society of anaesthesiologists physical class I & II

• Registration Number: CTRI/2017/08/009417
• Lead Sponsor: AIIMS Patna

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-03-06
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

•ASA (American society of anaesthesiologists) I & II physical grading

•Age between 18 to 60 years

•Elective Laparoscopic Cholecystectomy

Exclusion Criteria

•Patients belonging to ASA(American society of anaesthesiologists) physical status III, IV and V

•Patients with history of hypertension, diabetes

•Patients with fixed cardiac output status like aortic stenosis, mitral stenosis

•Patients with history of left ventricular failure, atrioventricular conduction block& severe cardiac disease

•Patients with known history of bronchial asthma, chronic obstructive pulmonary disease

•Patients with renal and hepatic derangements

•Patients taking clonidine, beta blocking drugs, calcium channel blockers, MAO inhibitors

•Elderly (age > 60 years) and age <18 years, Pregnant & lactating women

•History of allergy to α2 agonist

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of Dexmedetomidine loading and infusion dose on haemodynamic response during Laparoscopic cholecystectomy <br/ ><br>Any other adverse effects noted. <br/ ><br> <br/ ><br>Post operative Visual analogue score and Ramsay sedation score along with time of first rescue analgesic requirement notedTimepoint: â?¢Before starting infusion <br/ ><br>â?¢15 minutes after starting the infusion <br/ ><br>â?¢1 minute after induction <br/ ><br>â?¢1 minute after intubation <br/ ><br>â?¢1 minute after pneumoperitoneum <br/ ><br>â?¢15 minutes after pneumoperitoneum <br/ ><br>â?¢30 minutes after pneumoperitoneum <br/ ><br>â?¢45 minutes after pneumoperitoneum <br/ ><br>â?¢1 minute after release of pneumoperitoneum <br/ ><br>â?¢1 minute after extubation <br/ ><br> <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
â?¢Degree of Sedation during immediate post-operative period <br/ ><br>â?¢Analgesia during immediate post-operative period& time for first rescue analgesic requirement. <br/ ><br>Timepoint: 10 minutes after extubation