Comparison of the Neuroprotective Effect of Sevoflurane Versus Propofol in Patients Undergoing Endovascular Coiling of Cerebral Aneurysm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Concentration of interleukin-10
研究概览
简要总结
The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:
Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?
Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.
排除标准
- •have an endocrine system disease
- •pregnancy
- •have other brain disorders
- •take drugs that alter endocrine hormones
- •receive perioperative blood derivatives
研究组 & 干预措施
patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital
The present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia.
干预措施: Anesthesia Agent (Drug)
结局指标
主要结局
Concentration of interleukin-10
时间窗: From enrollment to 3 months postoperation
Test the concentration of interleukin-10 of the participants
次要结局
- Concentration of interleukin-1(From enrollment to 3 months postoperation)
- Concentration of interleukin-2(From enrollment to 3 months postoperation)
- Concentration of interleukin-6(From enrollment to 3 months postoperation)
- Concentration of interleukin-8(From enrollment to 3 months postoperation)
- Concentration of tumor necrosis factor(From enrollment to 3 months postoperation)
- Concentration of S100B(From enrollment to 3 months postoperation)
- length of stay(through study completion, an average of 6 months)
- costs(through study completion, an average of 6 months)
- Glasgow Coma Score(From enrollment to 3 months postoperation)
研究者
mingxin zhu
associate professor
Tongji Hospital