ow volume respiration during operation in patients with infection in abdome
- Conditions
- Health Condition 1: null- Peritonitis patients undergoing emergency laparotomy
- Registration Number
- CTRI/2014/12/005256
- Lead Sponsor
- AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Age > 18 yrs, <70 years
Emergency laparotomy expected duration >2hrs
Suspected or identified abdominal source of infection
Preoperative risk index for pulmonary complications >2
Mechanical ventilation within 2 weeks preceeding surgery
BMI >= 35
History of respiratory failure or sepsis within the 2 weeks preceding surgery
Requirement for intrathoracic surgery, history of lung surgery
History of severe COPD, with (non-invasive) ventilation and/or oxygen therapy at home and/or repeated systemic corticosteroid therapy for acute exacerbations of COPD
Progressive neuromuscular illness
ALI or acute respiratory distress syndrome expected to require prolonged post-operative
mechanical ventilation,
Persistent hemodynamic instability or intractable shock
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pulmonary complications occurring by day 7 after surgery in the form of acute respiratory failure, Pneumonia,ARDS, Pneumothorax <br/ ><br>Timepoint: Pulmonary complications occurring by day 7 after surgery in the form of acute respiratory failure, Pneumonia,ARDS, Pneumothorax <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Pulmonary complications graded on a scale 0 to 4 <br/ ><br>2.Ventilation related adverse events during surgery <br/ ><br>3.Severe sepsis, septic shock, organ dysfunction <br/ ><br>4.Number of days of ICU admission and duration of hospital stay <br/ ><br>5.Surgical complications like development of intraabdominal abscess, anastomotic leakage, unplanned re-exploration <br/ ><br>Timepoint: Within 7 days of surgery