Effect of intraoperative lung protective ventilation on cerebral hemodynamics (cerebral blood flow assessment using transcranial doppler, cerebral oxygenation by NIRS and ICPmeasurement using subdural catheter) in neurosurgical patients: a prospective observational study

SCTIMST0 个研究点目标入组 0 人开始时间: 待定最近更新: 2022年10月17日

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•1. Consenting adult patients undergoing craniotomy in supine position or anterior spinal surgery at Sree Chitra Tirunal Institute for Medical Sciences and Technology
•2.Age 18-60 yrs.
•3. ASA (American Society of Anaesthesiologists) class 1 and 2
•4. GCS 15 prior to the surgery

•1.Patient refusal
•2.Craniotomies other than supine position
•3.Spine surgeries in prone position
•4.Recent respiratory infection
•5.Patients with chronic lung disease or pulmonary infections 1 month before surgery
•6.Acute respiratory failure (pneumonia, acute lung injury, ARDS)
•7.Emergency surgery
•8.Patients with clinical signs (head ache, vomiting, confusion, papilledema, pupillary asymmetry) or radiological signs (midline shift > 1cm, presence of hydrocephalus) of raised intracranial pressure preoperatively.
•9.Long standing uncontrolled diabetes mellitus, systemic hypertension, cardiovascular disease, COPD
•10.Patients with previous history of stroke, transient ischemic attacks
•11.Obesity
•12.ASA class 3,4,5 patients
•13.Patients with subarachnoid haemorrhage, vasospasm
•14.Pregnant and lactating mothers
•15.Any abnormality in baseline NIRS and TCD values

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