The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Laboratory analysis of Tat Protein
研究概览
简要总结
Investigators in the Division of Infectious Diseases and the Departments of Biochemistry and Molecular Biology of The George Washington University Medical Center are carrying out a research study to determine why patients with Human Immunodeficiency Virus (HIV) and Hepatitis C virus (HCV) co-infection (HIV/HCV) have a more rapid and progressive course of HCV infection, leading to fatty infiltration of the liver and cirrhosis.
详细描述
Samples will be collected from 4 groups of patients with HIV/HCV infection, identified by the virologic control of either HIV, HCV, or both. Sera will be used in an in-vitro hepatocyte model of hepatitis C infection to better understand the pathogenesis of HIV/HCV co-infection, and to gain insight into intracellular mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets one of the following criteria:
- •detectable HIV RNA and detectable HCV RNA
- •undetectable HIV RNA (treated) and detectable HCV RNA
- •undetectable HIV RNA (treated) and undetectable HCV RNA
- •undetectable HCV RNA (mono-infected)
- •detectable HCV RNA (mono-infected)
- •detectable HIV RNA (mono-infected)
- •Participants will be men and women, ages 18 and older, and who are patients being seen in the clinics of the Medical Faculty Associates, and meet the above criteria.
排除标准
- 未提供
结局指标
主要结局
Laboratory analysis of Tat Protein
时间窗: Single sample analysis
The validation that HIV Tat protein is a potent inducer of HCV in dual infected patients will likely lead to anti-tat therapy to manage HCV patients for whom treatment options are rather limited.
次要结局
未报告次要终点