A Study of Circulating Immune Cell Activity Changes in Blood of Colorectal Cancer Patients
Completed
- Conditions
- Colorectal Cancer
- Interventions
- Device: Late stageDevice: Early stage
- Registration Number
- NCT02869269
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
Previous studies have shown that colorectal cancer patients' prognosis and overall survival was related with immune cell expression in patients' tissue. However, the circulating immune cell activity changes in patients' blood has few studies. The purpose of this study is to analyze the variation of circulating immune cell activity in colorectal patients' blood which is classed as clinical staging.
- Detailed Description
The patients were classed as clinical staging
1. Early (stage1+2) and Late(stage3+4)
2. regional lymph node metastasis
3. Distant metastasis
4. TNM stage
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 67
Inclusion Criteria
- patient who was planned to undergo colorectal cancer surgery.
Exclusion Criteria
- age < 20 years old
- history of hypersensitivity reaction in propofol or sevoflurane
- history of previous cancer
- patient with ongoing inflammation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Late stage Late stage patients who diagnosed as TNM stage 3 and 4 Early stage Early stage patients who diagnosed as TNM stage 1 and 2
- Primary Outcome Measures
Name Time Method Circulating helper T cell activity preoperative time change of expression level of T cell (0\~100 %)
- Secondary Outcome Measures
Name Time Method Cytotoxic T cell and natural killer cell activity preoperative time change of expression level Cytotoxic T cell and natural killer cell(0\~100 %)from 0 to 100)
Trial Locations
- Locations (1)
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of