Application of the Stem Cell Therapy in the End Stage Liver Disease and Assessment Its Consequences in the Quality of Live Style as Well as Development of HCC.

Brief Summary: Prospective study to calculated the incidence of hepatocellular carcinoma in hepatitis C virus infected patients after stem cell therapy.

Detailed Description: Our prospective research is carried out in one of the stem cell therapy centers in Egypt where 140 hepatitis C virus infected patients attending for stem cell therapy are enrolled in our study and the patients will be followed up after stem cell therapy where the incidence of hepatocellular carcinoma after stem cell therapy will be calculated , another group of hepatitis C virus infected patients attending to Kasr El Aini university hospital to receive the standered line of care as indicated will be enrolled in our study and will be followed up , where the incidence of hepatocellular carcinoma will be calculated and compared to the previous group , to determine if there is a significant difference between both groups regarding the incidence of hepatocellular and determine whether stem cell therapy affecets the incidence of hepatocellular carcinoma in hepatitis C virus infected patients.

Recruitment & Eligibility

Inclusion Criteria

Male or female patients aged from 20 to 65 years of age.
Evidence of chronic liver insufficiency.
The presence of decreased serum albumin and/or increased bilirubin and/or increased international normalized ratio (INR).
Patient is unlikely to receive a liver transplant.
Ability to give written consent
Women of childbearing potential may be included, but must use a reliable and appropriate contraceptive method

Exclusion Criteria

Patients below the age of 20 or above the age of 65 years
Pregnant or lactating women
Patients with recent recurrent GI bleeding or spontaneous bacterial peritonitis
Patients with evidence of HIV or other life threatening infection
Patients unable to give informed consent
Patients with a history of hypersensitivity to G-CSF
Patients who have been included in any other clinical trial within the previous month
Patient with recurrent attacks of hepatic encephalopathy.
Evedince of portal vein thrombosis by ultrasound.

Primary Outcome Measures

Name	Time	Method
Incidence of hepatocellular carcinoma post stem cell therapy in hepatitis C virus infected patients	within the first year after stem cell therapy

Secondary Outcome Measures

Name	Time	Method
Compare the incidence of hepatocellular carcinoma in patients who had received stem cell therapy to those who had received the standared line of care	within one year of follow up of hepatitis C virus infected patients

Receive instant email notifications about changes in this clinical trial

Receive instant email notifications about changes in this clinical trial