Evaluation of Von Willebrand Factor as a Marker For Early Diagnosis of Acute Respiratory Distress Syndrome (A.R.D.S) in Comparison to Interleukin 6 [IL-6]
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- level of vwf at 72 hours
研究概览
简要总结
In this prospective study of 60patients, we tested the hypothesis That markedly elevated levels of plasma von Willebrand factor (VWF) a marker of endothelial cell injury might predict the development of acute respiratory distress syndrome (A.R.D.S) in risky patients. We compared our result to IL.6 as control biomarker for A.R.D.S development.
Acute lung injury was quantified on two -point scoring system (Berlin definition of ARDS and Murray score of acute lung injury).
Plasma levels of both vWF and IL.6 were be measured on T=0 i.e. (at start of the study once the patient considered to be risky for A.R.D.S development to obtain their baseline levels), T=48 (after 48 hours), and T=72 (after 72 hours).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients between 18 and 80 years old of both sexes.
- •risk factor for development of acute respiratory distress syndrome or acute lung injury either by:
- •Direct lung injury includes: Severe pneumonia (infection), Breathing a vomited stomach contents (aspiration), Breathing harmful fumes or smoke, severe trauma to the chest or other accident that bruises the lungs.
- •Indirect lung injury includes: sepsis, Severe injury or trauma with shock, blood transfusions , drug overdose acute pancreatitis, fracture of the long bones, near drowning ,anaphylaxis, uremia, fat embolus , and intracranial insult.
排除标准
- •(1) pregnancy;
- •(2) a preexisting medical condition with a life expectancy less than 3 months
- •(3) evidence of cardiogenic pulmonary edema
- •(4) age under 18 years old or above 80 years old
- •(5) late stages of liver cell failure, renal failure
- •(6) severe myocardial infarction
- •(7) deep coma.
结局指标
主要结局
level of vwf at 72 hours
时间窗: 72 hours
Plasma levels of both vWF and IL.6 were be measured on T=0 i.e. (at start of the study once the patient considered to be risky for A.R.D.S development to obtain their baseline levels), T=48 (after 48 hours), and T=72 (after 72 hours).
次要结局
未报告次要终点
研究者
Dalia Elfawy
assistant professor of anesthiology and ICU , faculty of medicine , Ain Shams univeristy
Ain Shams University