Evaluation of Von Willebrand Factor as a Marker For Early Diagnosis of Acute Respiratory Distress Syndrome (A.R.D.S) in Comparison to Interleukin 6 [IL-6]

• Conditions: ARDS, Human
• Interventions: Diagnostic Test: VWF measurement

• Registration Number: NCT04317469
• Lead Sponsor: Ain Shams University

Brief Summary

In this prospective study of 60patients, we tested the hypothesis That markedly elevated levels of plasma von Willebrand factor (VWF) a marker of endothelial cell injury might predict the development of acute respiratory distress syndrome (A.R.D.S) in risky patients. We compared our result to IL.6 as control biomarker for A.R.D.S development.

Acute lung injury was quantified on two -point scoring system (Berlin definition of ARDS and Murray score of acute lung injury).

Plasma levels of both vWF and IL.6 were be measured on T=0 i.e. (at start of the study once the patient considered to be risky for A.R.D.S development to obtain their baseline levels), T=48 (after 48 hours), and T=72 (after 72 hours).

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-03
• Study First Submitted: 2020-03-18
• Study First Submitted QC: 2020-03-19
• Last Update Submitted: 2020-03-19
• Study Start: 2020-03-21
• Study First Posted: 2020-03-23
• Last Update Posted: 2020-03-23
• Primary Completion: 2021-03-20
• Study Completion: 2021-09-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients between 18 and 80 years old of both sexes.
• risk factor for development of acute respiratory distress syndrome or acute lung injury either by:
• Direct lung injury includes: Severe pneumonia (infection), Breathing a vomited stomach contents (aspiration), Breathing harmful fumes or smoke, severe trauma to the chest or other accident that bruises the lungs.
• Indirect lung injury includes: sepsis, Severe injury or trauma with shock, blood transfusions , drug overdose acute pancreatitis, fracture of the long bones, near drowning ,anaphylaxis, uremia, fat embolus , and intracranial insult.

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Exclusion Criteria

• (1) pregnancy;
• (2) a preexisting medical condition with a life expectancy less than 3 months
• (3) evidence of cardiogenic pulmonary edema
• (4) age under 18 years old or above 80 years old
• (5) late stages of liver cell failure, renal failure
• (6) severe myocardial infarction
• (7) deep coma.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non ARDS group	VWF measurement	-
ARDS group ,	VWF measurement	-

Primary Outcome Measures

Name	Time	Method
level of vwf at 72 hours	72 hours	Plasma levels of both vWF and IL.6 were be measured on T=0 i.e. (at start of the study once the patient considered to be risky for A.R.D.S development to obtain their baseline levels), T=48 (after 48 hours), and T=72 (after 72 hours).