NCT02102971终止不适用
Autophagy in Liver Injury: Changes in Autophagy Biomarkers During Liver Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Biochemical analysis of sirtuin1 from liver tissues during liver surgery
研究概览
简要总结
The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.
详细描述
If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver resection > 2 segments,
- •plate count > 100 x 109/L, and
- •prothrombin activity >60%.
排除标准
- •liver cirrhosis,
- •portal hypertension,
- •steatohepatitis or severe steatosis,
- •patients receiving additional ablation therapies,
- •laparoscopic resection, and
- •simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy
结局指标
主要结局
Biochemical analysis of sirtuin1 from liver tissues during liver surgery
时间窗: 30 minutes during liver surgery
次要结局
未报告次要终点
研究者
研究点 (1)
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