NCT02076932
Completed
N/A
A Training Intervention Study in Late Pre- and Early Postmenopausal Women Investigating the Changes in Adipose Tissue Metabolism and Peripheral Insulin Sensitivity
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Menopause
- Sponsor
- University of Copenhagen
- Enrollment
- 43
- Locations
- 1
- Primary Endpoint
- Hyperinsulinemic euglycemic clamp
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.
Investigators
Bente Merete Stallknecht
Professor, MD
University of Copenhagen
Eligibility Criteria
Inclusion Criteria
- •Premenopausal OR Postmenopausal (45-57 years)
- •No chronical Diseases
- •BMI \> 18,5 and \< 30
- •Sedentary (no regular physical activity the last 2 years)
- •Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal)
- •Plasma measurements:
- •Premenopausal: estradiol \> 0.20nmol/l, Follicle Stimulating Hormone \< 22 IU/l and progesterone \> 2.5 nmol/l Postmenopausal: estradiol \< 0.20nmol/l, Follicle Stimulating Hormone \> 22 IU/l and progesterone from 0.3-2.5 nmol/l
Exclusion Criteria
- •Excessive alcohol intake
- •Regular medication including hormone replacement treatment
Outcomes
Primary Outcomes
Hyperinsulinemic euglycemic clamp
Time Frame: Baseline and 3 months
Glucose metabolized (mg/kg/min)
Adipose tissue distribution
Time Frame: Baseline and 3 months
Accessed by Magnetic Resonance Imaging (MRI).
Insulin stimulated uptake of glucose in adipose tissue
Time Frame: Baseline and 3 months
Measured by Positron Emission Tomography-Computed tomography (PET/CT)
Secondary Outcomes
- Abdominal subcutaneous adipose tissue biopsy(Baseline and 3 months)
- Physical activity level and duration of sleep(Baseline and 3 months)
- Anthropometry(Baseline and 3 months)
- Resting metabolic rate(Baseline and 3 months)
- Health related quality of life(Baseline and 3 months)
- Central insulin sensitivity(Baseline and 3 months)
- Skeletal muscle biopsy(Baseline and 3 months)
- Femoral subcutaneous adipose tissue biopsy(Baseline and 3 months)
- Maximal oxygen uptake (ml/O2/kg/min)(Baseline and 3 months)
- Metabolic syndrome(Baseline and 3 months)
- Microdialysis(Baseline and 3 months)
Study Sites (1)
Loading locations...
Similar Trials
Unknown
N/A
Early Prevention of Childhood Obesity: an Active PregnancyPregnancyNCT02109588Technical University of Madrid1,100
Completed
N/A
An Exercise Intervention for Prostate Cancer Patients Receiving Androgen Deprivation TherapyProstate CancerPhysical ActivitySide-effectsNCT02248350Georgetown University19
Completed
Phase 2
The Effect of Exercise on Preventing PostPartum DepressionPostPartum DepressionNCT00961402University of Minnesota130
Completed
N/A
Physical Activity Intervention to Reduce Functional Health Disparities Among Breast Cancer SurvivorsBreast CancerPhysical ActivityNCT02763228Case Comprehensive Cancer Center218
Completed
N/A
Staying Healthy Through Education and Prevention StudyDisabilityNCT00817193LeadingAge320