TCTR20240409004
Not yet recruiting
Not Applicable
The Venous Excess Ultrasound (VExUS) grading to predict tolerance to fluid de-escalation in critically ill patients
Faculty of Medicine Ramathibodi Hospital, Mahidol University0 sites65 target enrollmentApril 9, 2024
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critically ill patientsCirculatory shockFluid de-escalation
- Sponsor
- Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Enrollment
- 65
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Adult patients (age 18 years and over) admitted in intensive care units (both medical and surgical ICU) of Ramathibodi Hospital
- •2\.Presence of fluid accumulation, defined as positive fluid balance 10% or more of body weight
- •3\.Hemodynamic stability, defined as
- •a. Adequate tissue perfusion (capillary refilling time less than 3 seconds)
- •b. Mean arterial pressure more than 65 mmHg with
- •i.Clearing decreasing dose of vasopressor
- •ii.Norepinephrine less than 0\.2 mcg/kg/min
- •iii.Arterial lactate level less than 2 mmol/L
- •4\.Need for fluid de\-escalation, as decided by the attending physicians
Exclusion Criteria
- •1\.Patients who refused to participate in the study or withdraw from the study
- •2\.Patients who had severe chronic kidney disease (estimated glomerular filtration rate less than 15 mL/min per 1\.73 m2 or in regular dialysis program) or renal transplantation
- •3\.Patients with obstacles to abdominal ultrasound include severe obesity (BMI of 40 or higher), having had abdominal surgery or having abdominal burn wounds in the positions that may impede ultrasound.
- •4\.Patients with previously known conditions that interfere with portal Doppler assessments (liver cirrhosis, portal vein thrombosis, or severe tricuspid regurgitation with structural heart disease)
- •5\.Pregnancy
Outcomes
Primary Outcomes
Not specified
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