The effects of vancomycin on gut bacteria and coagulation values in the blood.
Completed
- Conditions
- Venous thrombosis, gut microbiome, antibiotics, coagulation, complement, obesity.
- Registration Number
- NL-OMON20609
- Lead Sponsor
- The Arctic University of Norway, Tromsø, department of Clinical Medicine, TREC (Thrombosis Research and Expertise Center), Farmasibygget, 9037 Tromsø, Norge.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Eighteen years of age or older
-Not older than 40 years
Exclusion Criteria
-The use of any medication during the last month before the start of the study until the end of the study period (including oral contraceptives)
-Being post-partum or having used the contraceptive pill during the last 3 months before the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Factor VIII (FVIII:C)
- Secondary Outcome Measures
Name Time Method Individual coagulation parameters<br /><br>Parameters of inflammation (hs-CRP, TNF-alpha)<br /><br>Lipopolysaccharids in plasma<br /><br>Complement activity<br /><br>Changes in composition of the gut microbiome<br />