The change of Gut microbiota caused by Vonoprazan and kestose
Not Applicable
- Conditions
- Gastroduodenal ulcer and after ESD artificial ulcer
- Registration Number
- JPRN-UMIN000028803
- Lead Sponsor
- agoya University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients continuously using PPI or Vonoprazan 2. Women with pregnancy or possible pregnancy 3. Patients with severe renal failure and heart failure 4. Patient who is considered to be inappropriate for entry into the trial by the investigator 5. Medical doctors decided the patients are inappropriate 6. Patient who has allergy to drugs or foods used in this research
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the change of Gut microbiota caused by using Vonoprazan and kestose or placebo for 8 weeks
- Secondary Outcome Measures
Name Time Method 1. Ovserbation of the change of ulcer healing caused by kestose 2. Changes of short-chain fatty acid (Butyric acid,Acetic acid,Propionic acid etc.) 3. Changes of pathologic and metabolic marker (T.Cho, LDL-Cho, HDL-Cho, TG, FFA, ferritin,HbA1c,CRP,TP,ALB etc.) 4. Correlation of gut microbiota and bowel habits 5. Changes of body weight and BMI 6. Metabolome,bile acid and protein analysis of metabolite in feces 7. Correlation between expiratory noble gases,gut microbiota and ulcer healing