Prognostic Interest of Vasorin in Septic Shock
- Conditions
- SepsisAcute Kidney Injury
- Registration Number
- NCT06072508
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
In septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe Acute Kidney Injury (AKI). Vasorin (Vasn) is a protein strongly expressed in large vessels and kidneys, whose functions are still poorly known. Previous experimental studies show that Vasn is associated with decreased Angiotensin II concentrations, a vessel contractility defect and early mortality.
The investigators hypothesize that Vasn (the potential direct regulator of blood pressure) would be an early biomarker predicting the severity of AKI post septic shock, which may be associated with mortality from septic shock or lead to longer-term Chronic Renal Failure (CKD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Age ≥18 years old.
- Hospitalized in intensive care or medical resuscitation units.
- With a septic shock state defined by 2 mmol/l lactate sepsis, requiring vasopressors to maintain mean blood pressure 65 mmHg (despite adequate vascular filling).
- Whether or not they have developed AKI.
- Patient/family information and collection of non opposition
- Patients with chronic respiratory failure.
- Pregnant women.
- Patients in palliative care.
- Information for the patient/someone close and collection of his opposition
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method correlation between vasorin concentration at day 3 and mortality rate day 3 correlation between vasorin concentration at day 0 and mortality rate day 0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Amiens-Picardie
🇫🇷Amiens, France