ISRCTN64199452已完成未知
Influence of Pulse vs Spread protein distribution in combination with resistance exercise training on muscle protein synthesis, muscle strength and markers of inflammation in older women
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Aged 65 years or over
- •3. Ambulatory (with or without walking aids)
排除标准
- •1. Already engaging in regular exercise (at least twice a week)
- •2. History of myocardial infarction within previous 2 years
- •3. Cardiac illness: moderate/ severe aortic stenosis, acute pericarditis, acute myocarditis, aneurysm, severe angina,
- •4. Clinically significant valvular disease, uncontrolled dysrhythmia, claudication within the previous 10 years
- •5. Thrombophlebitis or pulmonary embolus within the previous 2 years
- •6. History of cerebrovascular disease (CVA or TIA) within the previous 2 years
- •7. Treatment with anticoagulants (Warfarin, rivaroxaban, apixaban, dabigatran) and antiplatelets (dipyridamole, clopidogrel, prasugrel, ticagrelor, glycoprotein IIb/IIIa antagonists). Nb. those regularly taking aspirin will be asked to stop for 3 days prior to biopsies and restart the day after
- •8. Acute febrile illness within the previous 3 months
- •9. Severe airflow obstruction
- •10. Uncontrolled metabolic disease (e.g., thyroid disease or cancer)
- •11. Significant emotional distress, psychotic illness or depression within the previous 2 years
- •12. Lower limb fracture sustained within the previous 2 years; upper limb fracture within the previous 6 months; non arthroscopic lower limb joint surgery within the previous 2 years
- •13. Any reason for loss of mobility for greater than 1 week in the previous 2 months or greater than 2 weeks in the previous 6 months
- •14. Resting systolic pressure >200 mmHg or resting diastolic pressure >100mmHg
- •15. Poorly controlled atrial fibrillation
- •16. Poor (chronic) pain control
- •17. Moderate/ severe cognitive impairment (MMSE <23)
- •18. Renal impairment (Stage 4 or 5)
研究者
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