Atorvastatin as an Antihypertensive Agent

Not Applicable

Completed

• Conditions: Atorvastatin Antihypertensive Effect
• Interventions: Drug: Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet; Drug: Amlodipine 5 MG Oral Tablet

• Registration Number: NCT05679102
• Lead Sponsor: Himayat Ullah

Brief Summary

This study is aimed to see the antihypertensive effect of statin (Atorvastatin) as certain animal models have shown that statins have the voltage-gated calcium channel blocking effect. It will be a randomized controlled trial that will be done in Ayub Hospital Complex Abbottabad. After ethical approval, 120 patients with newly diagnosed hypertension belonging to either gender and aged 35 and above will be enrolled in the trial. They will randomly be grouped into two groups with each group comprising 60 patients. One group will be administered Amlodipine 5 mg PO once a day, while the other one will be given 5mg Amlodipine plus 10 mg Atorvastatin. The patients will be examined on a follow-up visit 14 days later and blood pressure will be recorded as per protocols.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-20
• Status Verified: 2023-01
• Primary Completion: 2023-01-04
• Study Completion: 2023-01-04
• Study First Submitted: 2023-01-09
• Study First Submitted QC: 2023-01-09
• Last Update Submitted: 2023-01-09
• Study First Posted: 2023-01-10
• Last Update Posted: 2023-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• The inclusion criteria for the study were all newly diagnosed hypertensive patients aged 35 years and above with normal lipid profile

Exclusion Criteria

• Patients with a history of dyslipidemias, diabetes mellites, chronic kidney disease, and ischemic heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Amlodipine and Atorvastatin	Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet	Newly diagnosed hypertensive patients who will be given Amlodipine and Atorvastatin.
Amlopdipine only	Amlodipine 5 MG Oral Tablet	Newly diagnosed hypertensive patients who will be given only amlodipine.

Primary Outcome Measures

Name	Time	Method
Antihypertensive effect of atorvastatin	14 days	patients receiving atorvastatin based combination should have more decrease in the blood pressure.

Trial Locations

Locations (1)

Shaqra University; 🇸🇦 Shaqra, Riyadh, Saudi Arabia