Effect of Atorvastatin in the Management of Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Antihypertensive effect of atorvastatin
研究概览
简要总结
This study is aimed to see the antihypertensive effect of statin (Atorvastatin) as certain animal models have shown that statins have the voltage-gated calcium channel blocking effect. It will be a randomized controlled trial that will be done in Ayub Hospital Complex Abbottabad. After ethical approval, 120 patients with newly diagnosed hypertension belonging to either gender and aged 35 and above will be enrolled in the trial. They will randomly be grouped into two groups with each group comprising 60 patients. One group will be administered Amlodipine 5 mg PO once a day, while the other one will be given 5mg Amlodipine plus 10 mg Atorvastatin. The patients will be examined on a follow-up visit 14 days later and blood pressure will be recorded as per protocols.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria for the study were all newly diagnosed hypertensive patients aged 35 years and above with normal lipid profile
排除标准
- •Patients with a history of dyslipidemias, diabetes mellites, chronic kidney disease, and ischemic heart disease
研究组 & 干预措施
Amlopdipine only
Newly diagnosed hypertensive patients who will be given only amlodipine.
干预措施: Amlodipine 5 MG Oral Tablet (Drug)
Amlodipine and Atorvastatin
Newly diagnosed hypertensive patients who will be given Amlodipine and Atorvastatin.
干预措施: Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet (Drug)
结局指标
主要结局
Antihypertensive effect of atorvastatin
时间窗: 14 days
patients receiving atorvastatin based combination should have more decrease in the blood pressure.
次要结局
未报告次要终点
研究者
Himayat Ullah
Assistant Professor
Shaqra University