Genetic causes of cardiac arrest in patients with first heart attack

Recruiting

Conditions: Ventricular fibrillation
Circulatory System

Registration Number: ISRCTN17749344

Lead Sponsor: niversity Hospital of Copenhagen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 3000

Inclusion Criteria

Cases
1. First STEMI patients who experienced VF within the first 12 hours of symptoms of STEMI before PPCI
2. Age between 18 and 80 years
3. Caucasians
4. Cardiac symptoms lasting =12 hours
5. Acute ST-segment elevation revealed by ECG

Controls:
1. First STEMI patients who did not have VF during the first 12 hours of symptoms of STEMI before PPCI
2. Age between 18 and 80 years
3. Caucasians
4. Cardiac symptoms lasting =12 hours
5. Acute ST-segment elevation revealed by ECG

Exclusion Criteria

1. Cases and controls who developed VF during PPCI will be excluded because VF during PPCI is believed to be reperfusion induced; however, case patients with VF before PPCI who continued to have VF during PPCI can participate
2. Other exclusions included VF after PPCI
3. Congenital heart defects
4. Known structural heart disease
5. Use of class I and III antiarrhythmic drugs
6. Recent cancer
7. Major surgery or trauma within 4 weeks
8. Presentation with potassium concentration of <3 or >5 mmol/L
9. Because we also planned to identify genetic markers associated with VF, and because >90% of the Danish populations are white Danes, we excluded non-white Danes to reduce the risk of population stratification for future genetic analysis

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Common and rare genetic variants associated with ventricular fibrillation (VF) during first ST-elevation myocardial infarction (STEMI), analysed by genome-wide association studies and next generation sequencing

Secondary Outcome Measures