The pathophysiology of ventricular arrhythmia: does inflammation increase the risk of ventricular arrhythmia through hyperthermia and/or inflammatory cytokines?
- Conditions
- ventricular arrhythmiaventricular fibrillation10007521
- Registration Number
- NL-OMON32785
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Adult patients, who are eligible for the emplacement of an implantable cardioverter defibrillator (ICD) according to current guidelines (group 1); and adult patient with an ICD, who present after an episode of VT/VF and/or ICD discharge (group 2).
Exclusion Criteria
Patients using anti-pyretic or anti-inflammatory drugs.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Proportion of VT/VF and/or ICD discharge episodes that occur during<br /><br>hyperthermia (body temperature >37.5°), and serum levels of interleukin-6,<br /><br>interleukin-8 and CRP during each episode of VT/VF and/or ICD discharge.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Proportion of patients with ECG changes during hyperthermia or when serum<br /><br>levels of interleukin-6, interleukin-8 and/or CRP are increased.<br /><br>2. Changes in body temperature and serum levels of interleukin-6, interleukin-8<br /><br>and CRP that occurs during each episode of VT/VF and/or ICD discharge.<br /><br>3. Clinical variables (e.g., ischemia, heart failure, electrolyte imbalance,<br /><br>drug use) and cytokine gene variables that may determine the occurrence of<br /><br>VT/VF during inflammation.</p><br>