Role of Lipoprotein(a) Concentration and Apolipoprotein(a) Phenotype in Prediction of Coronary Events in General Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,400
- 主要终点
- non-fatal myocardial infarction and cardiovascular death
研究概览
简要总结
The purpose of this study is to explore the role of lipoprotein(a) and apolipoprotein(a) phenotype in fatal and non-fatal cardiovascular disease (CVD) events risk in coronary disease patients divided on the basis of management strategy - medical, endovascular or open cardiac surgery.
详细描述
Between January 1993 and September 2006, we enrolled 1400 consecutive patients from the Atherosclerosis Department with known Lp(a) levels and coronary heart disease (CHD) verified by angiography. In accordance with clinical condition and angiography data were assigned them into three parallel treatment arms and followed up to 15 years. This study was conducted according to the principles of the Declaration of Helsinki and the Institutional Ethics Committee.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable coronary heart disease verified by angiography
排除标准
- •acute coronary syndromes,
- •acute infections,
- •inflammatory disease within 3 months prior to inclusion,
- •familial hypercholesterolemia,
- •triglycerides>4.5 mmol/L,
- •missing Lp(a) measurements
结局指标
主要结局
non-fatal myocardial infarction and cardiovascular death
时间窗: up to 15 years
we took a composite primary outcome measure because anticipated a low number of hard-end-points in each treatment arm
次要结局
- non-fatal myocardial infarction and cardiovascular death and myocardial revascularisation and hospitalization for recurrent or unstable angina(up to 15 years)
研究者
Marat Vladislavovich Ezhov (MV Ezhov, MD, PhD, DMSc)
Associate Professor, Dr.
Russian Cardiology Research and Production Center