Regulation of Lipoprotein(a) Metabolism in Humans With Reference to Ethnicity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 325
- Locations
- 1
- Primary Endpoint
- Genetic variation of Lp(a) levels in each group
Study Overview
Brief Summary
The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.
The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.
Detailed Description
During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.
Study Design
- Study Type
- Observational
- Observational Model
- Family Based
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 6 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Of Caucasian or African descent
- •Families must have 2 natural/biological parents and 2 natural/biological offspring
- •6 years old or older
Exclusion Criteria
- •Races other than African American or Caucasian
- •Families without 2 natural/biological parents and 2 natural/biological offspring
- •younger that 6 years old
Outcomes
Primary Outcomes
Genetic variation of Lp(a) levels in each group
Time Frame: five years
Secondary Outcomes
No secondary outcomes reported