Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
- Conditions
- Shock
- Registration Number
- NCT03464747
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
During shock, arterial hypotension, inadequate cardiac output and microcirculatory alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is considered as the best marker of tissue hypoxia. A lactate decrease during the first 6 hour is strongly associated with better outcome and may be used as a target for assessing the efficiency of shock resuscitation.
The EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden) is a new device allowing the continuous measurement of venous lactate through a central venous catheter.
However, before being used extensively, such device needs to be evaluated concerning its accuracy. The aim of the present study is to assess the reliability of this device.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
Acute circulatory failure defined as : systolic blood pressure<90mmHg or mean arterial pressure <65mmHg and blood lactate > 2mmol/L
Pregnant women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Agreement Every 4hours for 48hours Agreement between sequential arterial blood lactate measurement and continuous venous lactate obtained by microdialysis
- Secondary Outcome Measures
Name Time Method Interchangeability Every 4hours for 48hours Interchangeability of the variations of the two methods using the trend interchangeability method
Trial Locations
- Locations (1)
CHU de Nîmes - Hôpital Universitaire Carémeau
🇫🇷Nîmes Cedex 9, France