TCTR20221011002
Completed
Phase 4
Acetaminophen and Chlorpheniramine Maleate Premedication in Chronically Transfused Patients: A Prospective, Randomized Controlled Trial
Supanat Janyangam0 sites94 target enrollmentOctober 11, 2022
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Efficacy of chlorpheniramine maleate and acetaminophen premedication in prevent febrile nonhemolytic transfusion reaction in chronically transfused patient.
- Sponsor
- Supanat Janyangam
- Enrollment
- 94
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patient receiving red cell transfusion at least 2 unit from the same cause in the last 3 months
- •2\. Hemoglobin level before transfusion is below 8 gm/dL
- •3\. At least 18 years of age
Exclusion Criteria
- •1\. Patient receiving red cell transfusion from acute blood loss
- •2\. Patient receiving red cell transfusion related to trauma
- •3\. Patient receiving red cell transfusion related to surgery
- •4\. History of febrile illness following transfusion in the last 3 months
- •5\. History of allergic reaction following transfusion in the last 3 months
- •6\. Acetaminophen allergy
- •7\. Chlorpheniramine maleate allergy
- •8\. Febrile illness within 24 hours prior to transfusion
- •9\. Allergic reaction within 24 hours prior to transfusion
- •10\. Patient receiving acetaminophen, chlorpheniramine maleate, other antihistamine, or corticosteroid equivalent to 5mg of prednisolone within 48 hours prior to transfusion
Outcomes
Primary Outcomes
Not specified
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