Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate: a Comparative Study of the Qualitative and Quantitative Electroencephalogram Pattern
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- electroencephalogram pattern
研究概览
简要总结
This study evaluates the use of dexmedetomidine or chloral hydrate for sedation during electroencephalography in patients with neurological disorders. The hypothesis is that this drugs provides similar changes in EEG pattern.
详细描述
Patients with chronic neurological disorders such as cerebral palsy or autism need to be sedated during electroencephalography (EEG). However, various sedatives and hypnotics affect the outcome of the review and is not shown. Chloral hydrate (CH) is widely used in children, but in this patients it is less effective.Recently, dexmedetomidine (DEX) has been tested because preliminary data suggests that this drug does not affect the EEG. The aim of the present work was to compare the electroencephalogram (EEG) pattern during CH or DEX sedation, to test the hypothesis that both drugs exert similar effects in EEG.Seventeen patients were evaluated during sedation with DEX or CH on separate occasions.The EEG was subjected to qualitative and quantitative analysis. Clinical variables were also compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 12 Years 至 38 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •neurological disorder
- •behavior disorder
排除标准
- •cardiac disease
- •respiratory disease
研究组 & 干预措施
dexmedetomidine, chloral hydrate
sedation with dexmedetomidine or chloral hydrate on separate occasions in the same patients
干预措施: Dexmedetomidine (Drug)
dexmedetomidine, chloral hydrate
sedation with dexmedetomidine or chloral hydrate on separate occasions in the same patients
干预措施: Chloral Hydrate (Drug)
结局指标
主要结局
electroencephalogram pattern
时间窗: twenty minutes
Qualitative analysis: identification of the deepest phase of sleep achieved during the examination, evaluation of background activity (normal, fast activity increased or slow activity increased). Quantitative analysis: density, duration, and amplitude of sleep spindles, spectral power and dominant frequence.
次要结局
- Effective sedative(twenty minutes)
- Adverse effects(Two hours)
研究者
Renato Santiago Gomez
Magda Lourenço Fernandes
Federal University of Minas Gerais