Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD)
- Conditions
- Developmental DyslexiaDevelopmental Coordination Disorder
- Interventions
- Behavioral: Neuropsychological assessmentOther: MRI Study
- Registration Number
- NCT02393729
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
All the studies underlined the high frequency of co-morbid associations in specific learning disorders. Understanding the reasons for these associations could enable us to determine the cerebral bases that underlie each disorder. Their frequent association suggests the etiological bases are partly common, it seems logical to turn to explanatory models of various common specific disorders. The model recently proposed by Nicholson \& Fawcett (2007) suggests a specific disorder of procedural learning. But the brain networks involved in this learning could be achieved separately. We intend therefore to study the neural networks involved in learning procedural and compare networks recruited among children with specific learning disorder alone or in combination (co-morbidity). The children included in the study have either a Developmental Dyslexia or a Developmental Coordination Disorder, or both. The procedure includes a neuropsychological evaluation and a brain MRI study with a morphological and a functional part. During fMRI the child realizes a automated motor task contrasting with a task involving learning procedural.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description children with DD Neuropsychological assessment Children with Developmental Dyslexia (DD) will have neuropsychological assessment and MRI study children with DCD + DD Neuropsychological assessment Neuropsychological assessment and MRI study children with DCD MRI Study Children with Developmental Coordination Disorder (DCD) will have neuropsychological assessment and MRI study children with DCD Neuropsychological assessment Children with Developmental Coordination Disorder (DCD) will have neuropsychological assessment and MRI study control children MRI Study Neuropsychological assessment and MRI study children with DCD + DD MRI Study Neuropsychological assessment and MRI study control children Neuropsychological assessment Neuropsychological assessment and MRI study children with DD MRI Study Children with Developmental Dyslexia (DD) will have neuropsychological assessment and MRI study
- Primary Outcome Measures
Name Time Method difference in the level of brain activity 1 day The difference in the level of brain activity obtained by contrasting the result of the automated task and that task with learning in the same patient-adjusted performance.
The level of brain activity obtained by fMRI 1 day The level of brain activity obtained by fMRI will be estimated by the blood flow in milliliters per minute using a standardized procedure and validated specific MRI used and managed entirely by dedicated software (SPM8 - Welcome Department of Cognitive Neurology, London, UK). The performance adjustment is made in the analysis of the estimated difference in blood flow using a mixed model. Regions of interest are the primary motor cortex, the supplementary motor area, the pre motor cortex, the striatum and the cerebellum. These regions will be studied in both hemispheres.
- Secondary Outcome Measures
Name Time Method The performance of subjects 1 day The performance of subjects evaluated in terms of frequency of movements in Hz and the number of erroneous restraints. The average frequency of movements for each block will be used as a covariate in the statistical analysis.
Trial Locations
- Locations (1)
Hôpital des Enfants
🇫🇷Toulouse, France