Stone Centre Urine and Serum Bank
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- genetic factors in stone disease
研究概览
简要总结
Purpose:
The purpose of the Stone Centre Serum and Urine Bank is to provide researchers with large numbers of serum and urine samples from kidney stone patients and controls for study of stone disease detection and treatment, and will take into account different genetic backgrounds, ages, and other patient factors to provide a broad sample size for the study of stone disease The Serum and Urine Bank will undoubtedly be an invaluable tool in the quest to understanding urinary stone disease.
Objective:
The objective of this research is to identify protein species or other compounds responsible for or contributing to kidney stone initiation and propagation.
详细描述
Background:
While great strides have been made in the surgical treatment of kidney stones, the means to identify high-risk patients for the prevention of kidney stones has lagged far behind. Urinary stone disease is a common problem, causes significant disability and sometimes death, and costs society 1.8 billion dollars each year. Therefore, it is important to identify those patients who are at risk or in the process of developing kidney stones and develop procedures which halt and/or prevent stone formation. Unfortunately, the current methods used for identifying such patients are inadequate. Kidney stone patients undergo urine and serum testing to attempt to identify substances that are either in excess or deficit in the body. The levels of these substances are then adjusted with diet modification and/or the use of medication. Often, patients who have corrected their abnormal values via diet or medications or others who have no identifiable risk factors continue to form stones. Clearly, current testing methods used to identify the continuous formation of stones are not enough, largely due to the fact that the causes of this disease are not completely understood.
There exists strong evidence supporting a role for proteins, both in promoting stone formation and in their prevention. Furthermore there may be hereditary factors (i.e. a family history) that may increase the risk of some patients becoming chronic kidney stone formers. This suggests a very complex cause of the disease and emphasizes the need and importance of identifying the genes and proteins involved in formation of stones.
Research Methods:
Urine and serum samples will be collected from study and control groups. Study group will be formed from confirmed kidney stone patients followed until post recovery, and the control group from healthy individuals. Control patients will have no history of kidney stone disease. Control subjects may be asked to undergo a screening renal ultrasound to ensure they are stone free.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Controls: age > 19 and no history of kidney stone disease);
- •Study (Stone Patient): Age > 19, radiological evidence indicating presence of a current renal or ureteric stone.
排除标准
- •Pregnancy,
- •Positive Urine Culture,
- •Active cancer,
- •Recurrent urinary infections,
- •Gross hematuria,
- •Inability to provide informed consent,
- •Investigator's refusal to include,
- •CONTROLS ONLY:
- •Family history of stones,
- •History of stones
结局指标
主要结局
genetic factors in stone disease
时间窗: one time sample
We are to determine the genetic factors that contributes to kidney stone disease from the microbiome analysis of urine and serum samples.
次要结局
未报告次要终点
研究者
Ben Chew, MD
Associate Professor
University of British Columbia